Baahida loo qabo daawaynta
COVID-19 waxa sababa caabuqa novel SARS-CoV-2 pathogen, kaas oo ka hawl gala oo gala unugyada martida loo yahay borotiinka sare.Waqtigan xaadirka ah, waxaa jira in ka badan 138.3 milyan oo kiisas la diiwaangeliyay adduunka oo dhan, iyadoo dhimashadu ay ku dhowdahay saddex milyan.
In kasta oo tallaallada loo oggolaaday isticmaalka degdegga ah, waxtarkooda ka hortagga qaar ka mid ah noocyada cusub ayaa la iswaydiiyay.Waxaa intaa dheer, daboolida tallaalka ee ugu yaraan 70% dadweynaha ku nool dhammaan waddamada adduunka waxay u badan tahay inay qaadato waqti dheer, iyadoo la tixgelinayo xawaaraha tallaalka hadda, yaraanta wax soo saarka tallaalka, iyo caqabadaha saadka.
Dunidu waxay wali u baahan doontaa dawooyin wax ku ool ah oo badbaado leh, sidaa awgeed, si ay u soo farageliso jirrooyinka halista ah ee uu keeno fayraskan.Dib-u-eegista hadda waxay diiradda saartaa shakhsiga iyo waxqabadka isku-dhafka ah ee curcumin iyo nanostructures ka dhanka ah fayraska.

Baahida loo qabo daawaynta
COVID-19 waxa sababa caabuqa novel SARS-CoV-2 pathogen, kaas oo ka hawl gala oo gala unugyada martida loo yahay borotiinka sare.Waqtigan xaadirka ah, waxaa jira in ka badan 138.3 milyan oo kiisas la diiwaangeliyay adduunka oo dhan, iyadoo dhimashadu ay ku dhowdahay saddex milyan.
In kasta oo tallaallada loo oggolaaday isticmaalka degdegga ah, waxtarkooda ka hortagga qaar ka mid ah noocyada cusub ayaa la iswaydiiyay.Waxaa intaa dheer, daboolida tallaalka ee ugu yaraan 70% dadweynaha ku nool dhammaan waddamada adduunka waxay u badan tahay inay qaadato waqti dheer, iyadoo la tixgelinayo xawaaraha tallaalka hadda, yaraanta wax soo saarka tallaalka, iyo caqabadaha saadka.
Dunidu waxay wali u baahan doontaa dawooyin wax ku ool ah oo badbaado leh, sidaa awgeed, si ay u soo farageliso jirrooyinka halista ah ee uu keeno fayraskan.Dib-u-eegista hadda waxay diiradda saartaa shakhsiga iyo waxqabadka isku-dhafka ah ee curcumin iyo nanostructures ka dhanka ah fayraska.

Curcumin
Curcumin waa ka samaysan polyphenolic oo ka go'doonsan rhizome ee geedka turmeric, Curcuma longa.Waxay ka kooban tahay curcuminoid-ka ugu weyn geedkan, 77% wadarta guud, halka isku-dhafka yar-yar ee curcumin II uu ka kooban yahay 17%, curcumin III wuxuu ka kooban yahay 3%.
Curcumin ayaa lagu sifeeyay oo si fiican loo bartay, sida molecule dabiici ah oo leh dawooyin.Dulqaadkeeda iyo badbaadadeeda si wanaagsan ayaa loo diiwaangeliyay, iyadoo ugu badnaan 12 g/maalintii.
Isticmaalkeeda ayaa lagu tilmaamay inay yihiin ka hortagga bararka, kansarka, iyo antioxidant, iyo sidoo kale ka hortagga fayraska.Curcumin waxaa loo soo jeediyay sidii unug leh awood uu ku bogsiiyo bararka sambabada iyo hababka kale ee dhaawaca ah ee u horseeda fibrosis sambabada ka dib COVID-19.

Curcumin wuxuu joojiyaa enzymes fayraska
Tan waxaa loo maleynayaa inay sabab u tahay awoodda ay u leedahay in ay iska ilaaliso fayraska laftiisa, iyo sidoo kale in ay wax ka beddesho waddooyinka caabuqa.Waxay xakameysaa qorista fayraska iyo nidaaminta, waxay ku xidhaa awood sare oo fayraska protease (Mpro) enzyme taas oo fure u ah soo saarista waxayna joojisaa ku xirnaanta fayraska iyo gelitaanka unugga martida loo yahay.Waxa kale oo laga yaabaa inay carqaladayso dhismayaasha fayraska.
Bartilmaameedyada kala duwan ee ka hortagga fayraska waxaa ka mid ah fayraska cagaarshow C, fayraska difaaca jirka aadanaha (HIV), fayraska Epstein-Barr iyo fayraska hargabka A.Waxaa la sheegay in ay joojiso 3C-sida protease (3CLpro) si ka waxtar badan marka loo eego alaabada kale ee dabiiciga ah, oo ay ku jiraan quercetin, ama daawooyinka sida chloroquine iyo hydroxychloroquine.
Tani waxay u oggolaan kartaa hoos u dhigista culeyska fayraska ee ku jira unugga bini'aadamka si aad uga dhaqso badan daawooyinka kale ee ka hortagga yar, oo sidaas awgeed ka hortagga u gudubka cudurka ee xanuunka neefsiga ee degdega ah (ARDS).
Waxa kale oo ay ka hortagtaa papain-like protease (PLpro) oo leh 50% xoojinta xakamaynta (IC50) ee 5.7 µM taas oo ka sarreysa quercetin iyo alaabta kale ee dabiiciga ah.

Curcumin waxay joojisaa soo-dhoweynta unugga martida loo yahay
Fayrasku wuxuu ku dheggan yahay soo-dhoweeyaha unugyada bartilmaameedka ah ee martida loo yahay, angiotensin-converting enzyme 2 (ACE2).Daraasadaha qaabaynta ayaa muujisay in curcumin ay u joojiso dhexgalka fayraska-receptor laba siyaabood, iyada oo la joojinayo labadaba borotiinka taranka iyo soo-dhoweeyaha ACE2.
Si kastaba ha ahaatee, curcumin waxay leedahay bioavailability hoose, sababtoo ah si fiican uma milaan biyaha oo waa mid aan degganayn warbaahinta aqueous, gaar ahaan pH sare.Marka afka laga maamulo, waxa uu maraa dheef-shiid kiimikaad degdeg ah mindhicirka iyo beerka.Caqabaddan waxaa looga gudbi karaa iyadoo la isticmaalayo nanosystems.
Sidayaal badan oo kala duwan oo nano habaysan ayaa loo isticmaali karaa ujeedadan, sida nanoemulsions, microemulsions, nanogels, miceles, nanoparticles iyo liposomes.Sidayaal noocan oo kale ah ayaa ka hortagaya burburka dheef-shiid kiimikaad ee curcumin, waxay kordhisaa milmaheeda waxayna ka caawiyaan inay u gudubto xuubka noolaha.
Saddex ama in ka badan oo alaabooyinka curcumin-ku-salaysan ee nanostructure-ku-salaysan ayaa horeba ganacsi ahaan loo helay, laakiin daraasado kooban ayaa baadhay waxtarkooda ka dhanka ah COVID-19 gudaha vivo.Kuwani waxay tuseen awoodda qaab-dhismeedka si ay wax uga beddelaan jawaab-celinta difaaca iyo in la yareeyo calaamadaha cudurka, lagana yaabo inay soo dedejiyaan soo kabashada.